We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Important features of the self-concept can be located outside of the individual and inside close or related others. The authors use this insight to reinterpret data previously said to support the empathy-altruism model of helping, which asserts that empathic concern for another results in selflessness and true altruism. That is, they argue that the conditions that lead to empathic concern also lead to a greater sense of self-other overlap, raising the possibility that helping under these conditions is not selfless but (...) is also directed toward the self. In 3 studies, the impact of empathic concern on willingness to help was eliminated when oneness--a measure of perceived self-other overlap--was considered. Path analyses revealed further that empathic concern increased helping only through its relation to perceived oneness, thereby throwing the empathy-altruism model into question. The authors suggest that empathic concern affects helping primarily as an emotional signal of oneness. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

How ought we differentiate the senses? What, say, distinguishes vision from audition? The question comes in two versions. First, there is the traditional problem of individuating the senses in humans. Second, there is also an important question about what sensory modalities we ought to attribute to non-human animals, a version of the question that has been virtually ignored by philosophers. Modality ought to be construed as an “avenue into” an organism for information external to the central nervous system. Six proposed (...) criteria found in the philosophical literature concerning the senses are reviewed. Initially, four criteria—physics, neurobiology, behavior, and evolutionary or developmental dedication—are shown to be individually necessary and jointly sufficient. Next, two criteria—Aristotle's proper objects of sensation criterion and Grice's sensation or qualia criterion—are considered and rejected. One overarching goal here is to show that there is interesting contemporary work left to be done on this ancient philosophical question. (shrink)

One issue within conspiracy theory theory is whether, or to what extent, our central concept – – should map on to the common, lay sense of the term. Some conspiracy theory theorists insist that we use the term as everyday people use it. So, for example, if the term has a pejorative connotation in everyday parlance, then academic work on the concept should reflect that. Other conspiracy theory theorists take a more revisionist approach, arguing instead that while their use of (...) the theoretical concept should bear some relation to its use in natural language, it need not follow it subserviently. I argue that elements of this debate mirror related debates that were prominent in the philosophy of mind in the 1980s over folk psychology and eliminative materialism (debates that continue today, such as within the philosophy of perception and theories over how to individuate the senses). Then, there was a debate over whether the concepts of commonsense psychology, such as or, should be treated as theoretical posits, and hence open to significant revision or elimination, or whether they were instead the targets of explanation. I will argue that an eliminativist approach to has significant merit. (shrink)

After first noting that I seek to broaden the definition of science fiction to a little more loosely defined speculative fiction, this essay explores four different ways in which fiction can work together with both the sciences and the philosophy of perception. This cooperation is needed because there is much about the sensory worlds of humans and non-human animals of which we continue to be ignorant. First, speculative fiction can be a source of hypotheses about the nature of the senses. (...) Second, it can help us understand the inner worlds of beings different from us. Third, speculative fiction often pushes us to investigate the ethical and social dimensions of sensory difference. Finally, speculative fiction can play an important role in reconciling our scientific understanding of the senses with a more commonsense understanding of same. (shrink)

Traditional secular conspiracy theories and explanations of worldly events in terms of supernatural agency share interesting epistemic features. This paper explores what can be called “supernatural conspiracy theories”, by considering such supernatural explanations through the lens of recent work on the epistemology of secular conspiracy theories. After considering the similarities and the differences between the two types of theories, the prospects for agnosticism both with respect to secular conspiracy theories and the existence of God are then considered. Arguments regarding secular (...) conspiracy theories suggest ways to defend agnosticism with respect to God from arguments that agnosticism is not a logically stable position and that it ultimately collapses into atheism, as has been argued by N. Russell Hanson and others. I conclude that such attacks on religious agnosticism fail to appreciate the conspiratorial features of God's alleged role in the universe. (shrink)

The charge that anthropomorphizing nonhuman animals is a fallacy is itself largely misguided and mythic. Anthropomorphism in the study of animal behavior is placed in its original, theological context. Having set the historical stage, I then discuss its relationship to a number of other, related issues: the role of anecdotal evidence, the taxonomy of related anthropomorphic claims, its relationship to the attribution of psychological states in general, and the nature of the charge of anthropomorphism as a categorical claim. I then (...) argue that the categorical reading of anthropomorphism cannot work and that it misrepresents what is being claimed when one claims that traits are shared between humans and nonhumans. We should think of such claims not as anthropomorphic per se– because that implies the trait is intrinsically human and only derivatively nonhuman. Instead, traits shared with mammals are mammalomorphic, for example, or primatomorphic when shared by primates. (shrink)

This paper explores the relationship between psychology and neurobiology in the context of cognitive science. Are the sciences that constitute cognitive science independent and theoretically autonomous, or is there a necessary interaction between them? I explore Fodor's Multiple Realization Thesis (MRT) which starts with the fact of multiple realization and purports to derive the theoretical autonomy of special sciences (such as psychology) from structural sciences (such as neurobiology). After laying out the MRT, it is shown that, on closer inspection, the (...) argument is either circular or self-undermining--the argument either assumes the very autonomy it seeks to demonstrate or the concluded autonomy is contradicted by the theoretical interdependence invoked by the premises of the argument. Next, I explore a concrete example of multiple realization in the explanation of animal behavior: the convergent evolution of jamming avoidance behaviors in three genera of weakly electric fish. Contrary to the image painted by the MRT, the work on these animals involves a high degree of interaction between the various levels of investigation. The fact that our understanding of electric fish behavior involves functional theories and multiple realization without the kind of disunified science that is supposed to follow from such a situation indicates that the mere fact of multiple realization cannot be the basis for an autonomous psychology. (shrink)

Largely a response to Lee Basham’s essay “Malevolent Global Conspiracy.” After presenting an update on the status of conspiracy theories surrounding the 1995 Oklahoma City bombing, I agree with Basham that falsification and paranoia are not effective ways to criticize conspiratorial thinking. However, I am not convinced with the case Basham presents against worries that conspiracy theories often falter by overestimating the ability of large, public institutions to be secretly and effectively controlled. His appeal to the historical record can be (...) read as suggesting that malevolent global action can be effectively carried out in full public view, obviating recourse to conspiracy. (shrink)

Efforts aimed at broadening participation in science, technology, engineering, and mathematics (STEM) require a holistic presentation of the state of racial and gender participation. Statistics currently used to describe participation often include raw counts of degrees and the percentages of demographic groups receiving STEM degrees. While these data provide insights into demographic trends, they do not present the complete picture because these “traditional” statistics do not capture how well a field of study reflects—or is proportionally similar to—a larger body, such (...) as the college population. If the goal of broadening participation in STEM education is to ensure that all racial and gender groups are proportionally represented, analysts require direct measures of representation. In this article, we present a novel metric that assesses the degree to which groups are overrepresented or underrepresented in a given field. This metric calculates field-specific representation by comparing the proportion of degrees awarded to members of a demographic group in a specific field of study with the proportion of all degrees awarded to that group. Using data from the National Science Foundation and the Department of Education, we demonstrate the efficacy of this representation metric and show that it provides new insights into STEM participation levels for women and other groups considered to be underrepresented. While traditional measurements show the increasing number of degrees awarded to and the increasing share of underrepresented minority students in STEM, our metric revealed that underrepresented minorities remain underrepresented in STEM fields, especially in engineering and the natural sciences. (shrink)

In the preface to his book God the Problem , Gordon Kaufman writes ‘Although the notion of God as agent seems presupposed by most contemporary theologians … Austin Farrer has been almost alone in trying to specify carefully and consistently just what this might be understood to mean.’.

This article advances the theoretical and practical value of workplace spirituality by drawing on person–organization (PO) fit theory and transpersonal psychology to investigate three questions: (a) What antecedents lead individuals and organizations to seek and foster workplace spirituality? (b) What are the perceived spiritual needs of individuals, and how are those needs fulfilled in the workplace? and (c) What are the consequences of meeting spiritual needs as individuals perceive them? Using constructivist grounded theory, analysis of interview data from thirty-four participants (...) located in organizations across the Netherlands, Ireland, the United Kingdom, and Portugal led to development of a workplace spirituality, PO fit model in which we propose reconciling self as a core factor of workplace spirituality. We note how through the process of reconciling self, workplace spirituality is related to meaning making and how an individual perceives their work environment as conducive to self-expression and inner purpose. Practical and theoretical implications are discussed, as are limitations of the study and ideas for future research. (shrink)

Technologies of communication condition human sense-making. They do so by creating the social environment we inhabit and extending their structural biases and logics through human use. As such, this essay inquires into the prevailing habits of mind in the digital era. Employing a media ecology of communication, I argue that digital computers and microprocessors are defined by three structural properties and, hence, underlying logics: digitization (binary code), algorithmic execution (input/output), and efficiency (machine logic). Repeated exposure to these logics cultivates a (...) digital mind, a model of thinking, communicating, and sense-making characterized by intransigence, impertinence, and impulsivity. I conclude the essay by exploring the broader implications of a digital mind, paying particular attention to the challenges it poses to democratic politics. (shrink)

Naturalism concerning the mental is the belief that the tools and concepts of natural science are necessary to achieve an understanding of the mind. After briefly setting the stage of naturalism and the mind, I pose the question of naturalism about the mind in its historical context, comparing the development of naturalist approaches to philosophy of mind to Russell's “hiving off” model of the history of Western philosophy, in which parts of philosophy have split away from the field as we (...) have developed new ways to answer questions once central to philosophy. Next, after distinguishing ontological from methodological senses of naturalism, I explore a number of different 20th‐century naturalist approaches to studying the mind, ending with a discussion of eliminative materialism and its stress on the continuity of scientific (naturalist) and commonsense understandings of the mind. (shrink)

Recent works have suggested an analytical complementarity in mixing big and thick data sources. These works have, however, remained as programmatic suggestions, leaving us with limited methodological inputs on how to archive such complementary integration. This article responds to this limitation by proposing a method for ‘blending’ big and thick analytical insights. The paper first develops a methodological framework based on the cognitivist linguistics terminology of ‘blending’. Two cases are then explored in which blended spaces are crafted from engaging big (...) and thick analytical insights with each other. Through these examples, we learn how blending processes should be conducted as a rapid, iterative and collaborative effort with respect for individual expertise. Further, we demonstrate how the unique, but often overlooked, granularity of big data plays a key role in affording the blending with thick data. We conclude by suggesting four commonly appearing blending strategies that can be applied when relying upon big and thick data sources. (shrink)

Neuroethology is a branch of biology that studies the neural basis of naturally occurring animal behavior. This science, particularly a recent program called computational neuroethology, has a similar structure to the interdisciplinary endeavor of cognitive science. I argue that it would be fruitful to conceive of cognitive science as the computational neuroethology of humans. However, there are important differences between the two sciences, including the fact that neuroethology is much more comparative in its perspective. Neuroethology is a biological science and (...) as such, evolution is a central notion. Its target organisms are studied in the context of their evolutionary history. The central goal of this paper is to argue that cognitive science can and ought to be more comparative in its approach to cognitive phenomena in humans. I show how the domain of cognitive phenomena can be divided up into four different classes, individuated by the relative phylogenetic uniqueness of the behavior. I then describe how comparative evidence can enrich our understanding in each of these different arenas. (shrink)

This collection offers an introduction to Churchland's work, as well as a critique of some of his most famous philosophical positions.

Face-to-face interaction is a primordial site for human activity and intersubjectivity. Empirical studies have shown how people reflexively exhibit a face orientation and work to establish a formation in which everyone is facing each other in local participation frameworks. The Face has also been described by, e.g., Levinas as the basis for a first ethical philosophy. Humans have established these Face-formations when interacting since time immemorial, but what happens when one of the participants is present through a telepresence robot? Based (...) on ethnomethodology, Peircean/goodwinian semiotics, multimodal conversation analysis and video data from a Danish residential rehabilitation center, the article shows the ways in which participants manage to interactively, cooperatively, and moment by moment achieve an F-formation in situ. The article contributes a detailed analysis and discussion of the kind of participant a telepresence robot is, in and through situated interactions: I propose that we term this participant the RoboDoc, given that it is an assemblage of a doctor who controls a robot. By focusing on the affordances of mobility, the article contributes to a renewed understanding of the importance and relevance of establishing Face-orientations in an increasingly technofied telepresence world. (shrink)

Artificial life (ALife) is the attempt to create artificial instances of life in a variety of media, but primarily within the digital computer. As such, the field brings together computationally-minded biologists and biologically-minded computer scientists. I argue that this new field is filled with interesting philosophical issues. However, there is a dearth of philosophers actively conducting research in this area. I discuss two books on the new field: Margaret A. Boden's The philosophy of artificial life and Christopher G. Langton's Artificial (...) life: an overview. They cover three areas of philosophical interest: the definition of life, the relationship between life and mind, and the possibility of creating life within a computational environment. This discussion allows me to critique past work in the philosophy of ALife that tends to see the field as a proving ground for traditional arguments from the philosophy of artificial intelligence. Instead, I suggest, what is interesting about ALife is how it differs from artificial intelligence and that the most interesting philosophical issues in the area are those derived from biology, not psychology. I recommend that these two books taken together constitute an interesting introduction to ALife and the wealth of philosophical issues found therein. (shrink)

This paper is a complement to the recent wealth of literature suggesting a strong philosophical relationship between artificial life (A-Life) and artificial intelligence (AI). I seek to point out where this analogy seems to break down, or where it would lead us to draw incorrect conclusions about the philosophical situation of A-Life. First, I sketch a thought experiment (based on the work of Tom Ray) that suggests how a certain subset of A-Life experiments should be evaluated. In doing so, I (...) suggest that treating A-Life experiments as if they were just AI experiments applied to a new domain may lead us to see problems (like Searle’s “Chinese room”) which do not exist. In the second half of the paper, I examine the reasons for suggesting that there is a philosophical relationship between the two fields. I characterize the strong thesis for a translation of AI concepts, metaphors, and arguments into A-Life as the “global replacement strategy.” Such a strategy is only fruitful inasmuch as there is a strong analogy between AI and A-Life. I conclude the paper with a discussion of two areas where such a strong analogy seems to break down. These areas relate to eliminative materialism and the lack of a “subjective” element in biology. I conclude that the burden of proof lies with the person who wishes to import a concept from another discipline into A-Life, even if that other discipline is AI. (shrink)

After first noting that I seek to broaden the definition of science fiction to a little more loosely defined speculative fiction, this essay explores four different ways in which fiction can work together with both the sciences and the philosophy of perception. This cooperation is needed because there is much about the sensory worlds of humans and non-human animals of which we continue to be ignorant. First, speculative fiction can be a source of hypotheses about the nature of the senses. (...) Second, it can help us understand the inner worlds of beings different from us. Third, speculative fiction often pushes us to investigate the ethical and social dimensions of sensory difference. Finally, speculative fiction can play an important role in reconciling our scientific understanding of the senses with a more commonsense understanding of same. (shrink)

In Western common sense, one speaks of there being five human senses, a claim apparently challenged by the biological and psychological sciences. Part of this challenge comes in the form of claiming the existence of additional senses. Part of the challenge comes from positing multiple senses where common sense only speaks of one, such as with the fractionation of “touch” into pressure and temperature senses. One conceptual difficulty in thinking about the number and division of senses is that it's not (...) clear whether the different senses constitute natural kinds and, if not, what kind of kind they are. Should we favor antirealism with respect to the senses, akin to the arguments of some concerning the nature of species or race? I will argue that this first problem is compounded by another: that we ought to be pluralists with respect to the senses—what is meant by the term “sense” varies from context to context, varying even between scientific contexts. (shrink)

The traditional perspective on self-deception, which assumes that the mind can be simultaneously involved in contradictory stories, and that there is an integrated understanding of the "truth" somewhere inside, is apparent in most contemporary theories of psychology. A critique of the phenomenon from a postmodern perspective raises questions regarding these assumptions. Ideas from evolutionary biology and research concerning hypnotically induced amnesia are used to support the thesis that self-deception is more a cultural phenomenon maintained by the observer, than a natural (...) phenomenon situated in the individual mind. (shrink)

We highlight the various domains of the flavivirus virulence factor NS1 and speculate on potential implications of the NS1 3D structure in understanding its role in flavivirus pathogenesis. Flavivirus non‐structural protein 1 (NS1) is a virulence factor with dual functions in genome replication and immune evasion. Crystal structures of NS1, combined with reconstructions from electron microscopy (EM), provide insight into the architecture of dimeric NS1 on cell membranes and the assembly of a secreted hexameric NS1‐lipid complex found in patient sera. (...) Three structural domains of NS1 likely have distinct roles in membrane association, replication complex assembly, and immune system avoidance. A conserved hydrophobic inner face is sequestered either on the membrane or in the interior of the secreted hexamer and contains regions implicated in viral replication. The exposed variable outer face is presented to cellular and secreted components of the immune system in infected patients and contains candidate regions for immune system modulation. We anticipate that knowledge of the distinct NS1 domains and assembly will lead to advances in elucidating virus‐host interactions mediated through NS1 and in dissecting the role of NS1 in viral genome replication. (shrink)

Background Families whose child has unexplained intellectual or developmental differences often hope that a genetic diagnosis will lower barriers to community-based therapeutic and support services. However, there is little known about efforts to mobilize genetic information outside the clinic or how socioeconomic disadvantage shapes and constrains outcomes.Methods We conducted an ethnographic study with predominantly socioeconomically disadvantaged families enrolled in a multi-year genomics research study, including clinic observations and in-depth interviews in English and Spanish at multiple time points. Coding and thematic (...) development were used to collaboratively interpret fieldnotes and transcripts.Results Thirty-two families participated. Themes included familial expectations that a genetic diagnosis could be translated into information, understanding, and assistance to improve the quality of a child’s day-to-day life. After sequencing, however, genetic information was not readily converted into improved access to services beyond the clinic, with families often struggling to use a genetic diagnosis to advocate for their child.Conclusion Families’ ability to use a genetic diagnosis as an effective advocacy tool beyond the clinic was limited by the knowledge and resources available to them, and by the eligibility criteria used by therapeutic service providers’ – which focused on clinical diagnosis and functional criteria more than etiologic information. All families undertaking genomic testing, particularly those who are disadvantaged, need additional support to understand the limits and potential benefits of genetic information beyond the clinic. (shrink)

It is suggested that the impetus to generate models is probably the most fundamental point of connection between mysticism and psychology. In their concern with the relation between ‘unseen’ realms and the ‘seen’, mystical maps parallel cognitive models of the relation between ‘unconscious’ and ‘conscious’ processes. The map or model constitutes an explanation employing terms current within the respective canon. The case of language mysticism is examined to illustrate the premise that cognitive models may benefit from an understanding of the (...) kinds of experiences gained, and explanatory concepts advanced, within mystical traditions. Language mysticism is of particular interest on account of the central role thought to be played by language in relation to self and the individual's construction of reality. The discussion focuses on traditions of language mysticism within Judaism, in which emphasis is placed on the deconstruction of language into primary elements and the overarching significance of the divine Name. Analysis of the detailed techniques used suggests ways in which multiple associations to any given word/concept were consciously explored in an altered state. It appears that these mystics were consciously engaging with what are normally preconscious cognitive processes, whereby schematic associations to sensory images or thoughts are activated. The testimony from their writings implies that these mystics experienced distortions of the sense of self , which may suggest that, in the normal state, ‘I’ is constructed in relation to the preconscious system of associations. Moreover, an important feature of Hebrew language mysticism is its emphasis on embodiment -- specific associations were deemed to exist between the letters and each structure of the body. Implications, first, for the relationship between language and self, and, second, for the role of embodiment in relation to self are discussed. The importance of the continual emphasis on the Name of God throughout the linguistic practices may have provided a means for effectively replacing the cognitive indexing function hypothesized here to be normally played by ‘I’ with a more transpersonal cognitive index, especially in relation to memory. (shrink)

In this paper, we study the interactional organization of an instructed object exploration among sighted and visually impaired people (VIPs) in order to contribute to studies of instructional activities and the observable accomplishment of haptic perception. We do this by showing the situated, interactional, and co-operative organization of achieving object understanding. We focus on the dynamics of haptic perception as being reliant on instructions, while at the same time being an observable production that furnishes further instructions. We show the organization (...) of visual and verbal instructions versus the touching of objects for haptic perception. Based on ethnomethodological conversation analysis of video data, we study a VIP’s haptic actions in interaction with a professional, sighted ICT consultant who provides instructions on what an object is and what it can do. We show how the instructions are sequentially adjusted to make them relevant for a simultaneous, emerging exploration in which the VIP uses their hands and fingers to perceive very specific details of the object. We argue that achieving object understanding is accomplished in and through the fine-tuned coordination of haptic exploration, both as a response to verbal instructions and also as a means of conveying perception-related actions, which the ICT uses to build new actions. The paper thus makes a case for instructed and distributed haptic perception as observable in social interaction and as a resource for building object understanding within phenomenal fields. (shrink)